Integration of cytokine and heterologous receptor signaling pathways

Nat Immunol. 2009 Apr;10(4):333-9. doi: 10.1038/ni.1713. Epub 2009 Mar 19.


Cytokines are soluble mediators of cell communication that are critical in immune regulation. They induce specific gene-expression programs in responsive cells. Recent findings, however, indicate that cytokine receptors can regulate immune cell functions by transcription-independent mechanisms. Here we review the current understanding of how cytokine signaling regulates the functions of other signaling pathways by first discussing the 'traditional' transcription-mediated consequences of cytokine signaling and then providing a detailed description of transcription-independent lateral communications between cytokine receptors and other cellular receptors.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Communication / immunology*
  • Cytokines / immunology*
  • Humans
  • Janus Kinases / immunology
  • Models, Biological
  • Receptor Cross-Talk / immunology
  • Receptors, Cytokine / immunology*
  • STAT Transcription Factors / immunology
  • Signal Transduction / immunology*
  • Transcription, Genetic


  • Cytokines
  • Receptors, Cytokine
  • STAT Transcription Factors
  • Janus Kinases