Semaphorin3A immunohistochemical expression in human meningiomas: correlation with the microvessel density

Virchows Arch. 2009 May;454(5):563-71. doi: 10.1007/s00428-009-0757-3. Epub 2009 Mar 19.


The immunoexpression of the antiangiogenic factor semaphorin3A (SEMA3A) was evaluated in a series of meningiomas. Then, its correlations with the microvessel density (MVD) of the tumors and with the clinicopathological parameters as well with the survival time or recurrence-free interval were investigated. A positive SEMA3A immunostaining was found in most of meningiomas and a significant association was found between a high expression of this protein and a low MVD of the tumors. Moreover, a low SEMA3A immunoexpression was significantly correlated with a higher recurrence rate of meningiomas. In conclusion, our findings suggest a role for SEMA3A as an antiangiogenic factor in meningiomas with its decrease being associated with the development of recurrences. The supplementation of SEMA3A might be used in novel therapeutic antiangiogenic strategies to prevent the recurrence of highly vascularized meningiomas.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Biomarkers, Tumor / metabolism
  • Female
  • Fluorescent Antibody Technique, Direct
  • Humans
  • Immunoenzyme Techniques
  • Male
  • Meningeal Neoplasms / blood supply
  • Meningeal Neoplasms / metabolism*
  • Meningeal Neoplasms / surgery
  • Meningioma / blood supply
  • Meningioma / metabolism*
  • Meningioma / surgery
  • Microvessels / pathology
  • Middle Aged
  • Neoplasm Recurrence, Local
  • Neovascularization, Pathologic
  • Semaphorin-3A / metabolism*


  • Biomarkers, Tumor
  • SEMA3A protein, human
  • Semaphorin-3A