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Meta-Analysis
. 2009 Mar;85(3):196-213.
doi: 10.1080/09553000902748575.

Genetic Damage in Mammalian Somatic Cells Exposed to Extremely Low Frequency Electro-Magnetic Fields: A Meta-Analysis of Data From 87 Publications (1990-2007)

Affiliations
Meta-Analysis

Genetic Damage in Mammalian Somatic Cells Exposed to Extremely Low Frequency Electro-Magnetic Fields: A Meta-Analysis of Data From 87 Publications (1990-2007)

Vijayalaxmi et al. Int J Radiat Biol. .

Abstract

Purpose: A meta-analysis was conducted to obtain a 'quantitative' estimate of the extent of genetic damage in mammalian somatic cells exposed to non-ionizing radiation emitted from extremely low frequency electro-magnetic fields (ELF-EMF) and to compare with that in unexposed control cells.

Methods: The methods used for the meta-analysis were recommended in several standard text books. Three specific variables related to ELF-EMF exposure characteristics were examined in the meta-analysis: (i) frequency (Hz), (ii) flux density (mT), and (iii) in occupationally exposed individuals.

Result and conclusions: (1) The difference between ELF-EMF-exposed and control cells as well as the 'effect size' due to ELF-EMF exposure were biologically small (although statistically significant) with very few exceptions. (2) At certain ELF-EMF exposure conditions there was a statistically significant increase in genetic damage assessed from some end-points. (3) The mean indices for chromosomal aberrations and micronuclei end-points in ELF-EMF-exposed and control cells were within the spontaneous levels reported in historical database. (4) Considerable evidence for publication bias was found in the meta-analysis.

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