Pd(II)-catalyzed olefination of electron-deficient arenes using 2,6-dialkylpyridine ligands

J Am Chem Soc. 2009 Apr 15;131(14):5072-4. doi: 10.1021/ja900327e.

Abstract

Pd(II)-catalyzed meta-olefination of highly electron-deficient arenes is achieved through the use of a rationally designed mutually repulsive ligand. The combination of directed and nondirected C-H functionalization of arenes provides a versatile route for the synthesis of highly sought after 1,2,4-trisubstituted arenes.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkenes / chemistry*
  • Catalysis
  • Electrons
  • Hydrocarbons, Aromatic / chemical synthesis
  • Hydrocarbons, Aromatic / chemistry*
  • Ligands
  • Palladium / chemistry*
  • Pyridines / chemistry*

Substances

  • Alkenes
  • Hydrocarbons, Aromatic
  • Ligands
  • Pyridines
  • Palladium