Photocyclization of tosylstilbenes as a key reaction in the preparation of an analogue of the antitumor agent CC-1065

J Org Chem. 2009 Apr 17;74(8):3203-6. doi: 10.1021/jo900140t.

Abstract

A photocyclization of tosylstilbenes in the presence of base is used as a key reaction in the synthesis of the CC-1065 analogue 5.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkaloids / chemical synthesis*
  • Alkaloids / chemistry
  • Antineoplastic Agents / chemical synthesis*
  • Antineoplastic Agents / chemistry
  • Cyclization*
  • Duocarmycins
  • Indoles / chemical synthesis*
  • Indoles / chemistry
  • Molecular Structure
  • Photochemistry*
  • Stilbenes / chemical synthesis*
  • Stilbenes / chemistry*
  • Tosyl Compounds / chemical synthesis*
  • Tosyl Compounds / chemistry*

Substances

  • Alkaloids
  • Antineoplastic Agents
  • Duocarmycins
  • Indoles
  • Stilbenes
  • Tosyl Compounds
  • CC 1065