Aquareovirus effects syncytiogenesis by using a novel member of the FAST protein family translated from a noncanonical translation start site

J Virol. 2009 Jun;83(11):5951-5. doi: 10.1128/JVI.00171-09. Epub 2009 Mar 18.


As nonenveloped viruses, the aquareoviruses and orthoreoviruses are unusual in their ability to induce cell-cell fusion and syncytium formation. While an extraordinary family of fusion-associated small transmembrane (FAST) proteins is responsible for orthoreovirus syncytiogenesis, the basis for aquareovirus-induced syncytiogenesis is unknown. We now report that the S7 genome segment of an Atlantic salmon reovirus is polycistronic and uses a noncanonical CUG translation start codon to produce a 22-kDa integral membrane protein responsible for syncytiogenesis. The aquareovirus p22 protein represents a fourth distinct member of the FAST family with a unique repertoire and arrangement of structural motifs.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Cell Line
  • Chlorocebus aethiops
  • Genome, Viral / genetics
  • Giant Cells / cytology*
  • Giant Cells / metabolism*
  • Membrane Proteins / chemistry
  • Membrane Proteins / classification
  • Membrane Proteins / genetics
  • Membrane Proteins / metabolism*
  • Molecular Sequence Data
  • Open Reading Frames / genetics
  • Protein Biosynthesis / genetics*
  • Reoviridae / genetics
  • Reoviridae / metabolism*
  • Salmo salar / virology
  • Viral Proteins / chemistry
  • Viral Proteins / classification
  • Viral Proteins / genetics
  • Viral Proteins / metabolism*
  • Virus Internalization


  • Membrane Proteins
  • Viral Proteins

Associated data

  • GENBANK/FJ652575
  • GENBANK/FJ652576