Abstract
The hemagglutinin-neuraminidase glycoprotein of Newcastle disease virus (NDV) was obtained as a recombinant antigen in Rachiplusia nu larvae. When it was used as an immunogen in chickens, a solid immune response, including neutralizing antibodies, was detected, demonstrating the potential use of this simple and economic strategy in the design of recombinant anti-NDV vaccines.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Animals, Genetically Modified
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Antibodies, Viral / blood
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Chickens
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HN Protein / immunology*
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Insecta / genetics
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Insecta / metabolism
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Larva / genetics
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Larva / metabolism
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Neutralization Tests
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Newcastle Disease / prevention & control*
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Newcastle disease virus / immunology*
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Poultry Diseases / prevention & control*
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Vaccines, Synthetic / immunology
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Viral Vaccines / immunology*
Substances
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Antibodies, Viral
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HN Protein
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Vaccines, Synthetic
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Viral Vaccines