Several organizations have banded together to create the People Living with HIV Stigma Index. In this article, which is based on a presentation at a concurrent session at the conference, Lucy Stackpool-Moore and Anandi Yuvaraj describe the purpose of the index and how it was developed. The authors believe that the index provides a real opportunity to measure, understand and advocate effectively to improve policies and programs and to make a real difference in the lives of people living with HIV.