Nevus spilus with synchronous melanomas: case report and literature review

J Cutan Med Surg. Mar-Apr 2009;13(2):96-101. doi: 10.2310/7750.2008.07090.


Background: Nevus spilus is a rare, acquired, and often large cutaneous lesion consisting of a light brown background macule containing varying numbers of small darker macular or papular areas.

Objective: Nevus spilus may contain dysplastic melanocytic elements, and there are also reports of melanoma arising from nevus spilus. However, the absolute risk for malignant transformation is not well defined.

Conclusion: We discuss a case of synchronous melanomas arising from a nevus spilus and potential management recommendations based on a review of the pertinent literature.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Humans
  • Male
  • Melanocytes / pathology
  • Melanoma / pathology*
  • Melanoma / surgery
  • Middle Aged
  • Neoplasms, Multiple Primary / pathology*
  • Neoplasms, Multiple Primary / surgery
  • Nevus / pathology*
  • Nevus / surgery
  • Nevus / therapy
  • Sentinel Lymph Node Biopsy
  • Skin Neoplasms / pathology*
  • Skin Neoplasms / surgery
  • Skin Neoplasms / therapy