Lipoprotein lipase expression in livers of morbidly obese patients could be responsible for liver steatosis

Obes Surg. 2009 May;19(5):608-16. doi: 10.1007/s11695-009-9827-5. Epub 2009 Mar 20.


Background: Most patients with morbid obesity develop non-alcoholic fatty liver disease (NAFLD). The origins of lipid deposition in the liver and the effects of bariatric surgery in the obese with NAFLD are controversial.

Methods: We analyzed lipids and lipoprotein lipase (LPL) in both plasma and liver biopsies performed before and 12-18 months after Roux-en-Y gastric bypass surgery in 26 patients.

Results: In the livers of morbidly obese patients, the levels of LPL messenger RNA (mRNA) were higher (4.5-fold) before surgery than afterwards than control livers. In these patients, LPL activity was also significantly higher (91 +/- 7 mU/g) than in controls (51 +/- 3 mU/g, p = 0.0026) and correlated with the severity of the liver damage. All hepatic lipids were significantly increased in obese patients; however, after bariatric surgery, these lipids, with the exception of NEFA, tended to recover to normal levels.

Conclusions: The liver of obese patients presented higher LPL activity than controls, and unlike the controls, this enzyme could be synthesized in the liver because it also present LPL mRNA. The presence of the LPL activity could enable the liver to capture circulating triacylglycerides, thus favoring the typical steatosis observed in these patients.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Body Mass Index
  • Case-Control Studies
  • Cohort Studies
  • Fatty Liver / etiology
  • Fatty Liver / metabolism*
  • Fatty Liver / pathology
  • Female
  • Gastric Bypass
  • Humans
  • Lipids / blood
  • Lipoprotein Lipase / genetics
  • Lipoprotein Lipase / metabolism*
  • Liver / enzymology*
  • Male
  • Middle Aged
  • Obesity, Morbid / complications*
  • Obesity, Morbid / enzymology*
  • Obesity, Morbid / surgery
  • RNA, Messenger / metabolism


  • Lipids
  • RNA, Messenger
  • Lipoprotein Lipase