Angiogenic signalling pathways

Methods Mol Biol. 2009;467:3-24. doi: 10.1007/978-1-59745-241-0_1.


Hypoxia is widely recognised as a key driving force for tumor angiogenesis by its induction of vascular endothelial growth factor (VEGF) and other direct-acting angiogenic factors. We describe the effect of hypoxia on gene expression and downstream angiogenic signalling; however, the angiogenic process is complex, and many other signalling pathways beyond VEGF are implicated in the formation of new vessels. These include extra-cellular signalling pathways such as the notch/delta, ephrin/Eph receptor, roundabout/slit, and netrin/UNC (uncoordinated) receptor families as well as intracellular proteins such as hedgehog and sprouty. The remarkable diversity in angiogenic signalling pathways provides many opportunities for therapeutic intervention, and anti-angiogenesis is currently a major area of oncology research.

Publication types

  • Review

MeSH terms

  • Animals
  • Humans
  • Hypoxia / metabolism*
  • Intercellular Signaling Peptides and Proteins / metabolism
  • Neovascularization, Physiologic*
  • Signal Transduction*


  • Intercellular Signaling Peptides and Proteins