Altered brain activation during response inhibition in obstructive sleep apnea

J Sleep Res. 2009 Jun;18(2):204-8. doi: 10.1111/j.1365-2869.2008.00707.x. Epub 2009 Mar 12.


This study examined response inhibition during a Go-NoGo task in individuals with obstructive sleep apnea (OSA). Fourteen OSA patients and 14 controls were studied with functional magnetic resonance imaging. Compared to controls, the OSA group showed more false positives (error of commission) during the NoGo trials with decreased brain activation in the left postcentral gyrus, cingulate gyrus and inferior parietal lobe, as well as right insula and putamen. This is consistent with previous findings of impaired performance and decreased brain activation in OSA patients during a working memory task, suggesting that compromised brain function in response to cognitive challenges may underlie some of the cognitive deficits seen in patients with OSA.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Arousal / physiology*
  • Attention / physiology*
  • Brain / physiopathology*
  • Brain Mapping
  • Dominance, Cerebral / physiology
  • Female
  • Humans
  • Inhibition, Psychological*
  • Magnetic Resonance Imaging*
  • Male
  • Memory, Short-Term / physiology*
  • Middle Aged
  • Motivation
  • Polysomnography
  • Psychomotor Performance / physiology*
  • Sleep Apnea, Obstructive / physiopathology*
  • Sleep Apnea, Obstructive / psychology