Correlation of serum interleukin-6 levels with joint involvement and thrombocytosis in systemic juvenile rheumatoid arthritis

Arthritis Rheum. 1991 Sep;34(9):1158-63. doi: 10.1002/art.1780340912.


We measured interleukin-6 (IL-6) levels in 70 serum samples obtained from 25 patients with systemic-onset juvenile rheumatoid arthritis (JRA), using the hybridoma cell line B9. Patients with systemic-onset JRA had significantly elevated serum IL-6 levels during active disease (mean +/- SD 92.1 +/- 75.1 hybridoma growth factor units/ml; P less than 0.00001 versus healthy age-matched controls), but not during remission. Serum IL-6 levels correlated with the extent and severity of joint involvement (P less than 0.001) and with platelet counts (P less than 0.05). Our data suggest that IL-6 plays a significant role in the pathogenesis of systemic-onset JRA.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Arthritis, Juvenile / blood*
  • Arthritis, Juvenile / etiology
  • Arthritis, Juvenile / pathology
  • Child
  • Child, Preschool
  • Humans
  • Interleukin-6 / blood*
  • Interleukin-6 / physiology
  • Joints / pathology*
  • Thrombocytosis / blood*
  • Thrombocytosis / etiology
  • Thrombocytosis / pathology


  • Interleukin-6