Dynamics of T cell activation accompanying CD4 recovery in antiretroviral treated HIV-infected Ugandan children

Clin Immunol. 2009 Jun;131(3):410-4. doi: 10.1016/j.clim.2009.01.016. Epub 2009 Mar 19.


Africans have elevated T cell activation compared to residents of Europe or the USA. Levels of T cell activation also correlate with disease progression in HIV-infected individuals. We sought to determine if treatment with antiretroviral therapy (ART) would reduce levels of T cell activation (CD38 and HLADR co-expression) in HIV-infected Ugandan children. The median CD8+ T cell activation level among 199 ART-treated children (30%) was lower than in 57 ART-naïve children (45%, p<0.001), but remained higher than in 30 HIV-uninfected children (18%, p<0.001). Among ART-treated children, CD4% was inversely correlated with both CD8- (rho=-0.61, p<0.001) and CD8+ (rho=-0.38, p<0.001) T cell activation. Prospectively, CD4 recovery correlated with post-treatment CD8+ T cell activation level (p=0.008). Our data suggest that significant decreases in T cell activation accompany CD4 recovery in ART-treated HIV-infected African children, to levels that approach but do not reach those of uninfected children.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • ADP-ribosyl Cyclase 1 / immunology
  • ADP-ribosyl Cyclase 1 / metabolism*
  • Anti-HIV Agents / administration & dosage*
  • CD4-Positive T-Lymphocytes / immunology*
  • CD4-Positive T-Lymphocytes / metabolism
  • CD4-Positive T-Lymphocytes / virology
  • CD8-Positive T-Lymphocytes / immunology*
  • CD8-Positive T-Lymphocytes / metabolism
  • CD8-Positive T-Lymphocytes / virology
  • Child
  • Child, Preschool
  • Cross-Sectional Studies
  • HIV Infections / drug therapy*
  • HIV Infections / immunology
  • HLA-DR Antigens / immunology
  • HLA-DR Antigens / metabolism*
  • Humans
  • Infant
  • Lymphocyte Activation / immunology*
  • Uganda


  • Anti-HIV Agents
  • HLA-DR Antigens
  • ADP-ribosyl Cyclase 1