Thrombus resolution and vein wall injury: dependence on chemokines and leukocytes

Thromb Res. 2009;123 Suppl 4:S72-8. doi: 10.1016/S0049-3848(09)70148-3.

Abstract

Chronic venous insufficiency resulting in post-thrombotic syndrome occurs commonly after acute deep vein thrombosis, and is a prevalent cause of vascular disease morbidity in the community. Therefore, a better understanding of the pathophysiologic mechanisms that promote the development of chronic venous insufficiency could lead to novel approaches to interrupt the natural history and prevent post-thrombotic syndrome. In this paper, we will review the evidence that venous thrombus resolution is an inflammatory process that is dependent on chemokines and leukocytes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cell Transdifferentiation
  • Chemokines / metabolism*
  • Chronic Disease
  • Humans
  • Inflammation / complications
  • Inflammation / immunology*
  • Inflammation / pathology
  • Inflammation / therapy
  • Intercellular Signaling Peptides and Proteins / metabolism
  • Leukocytes / immunology*
  • Male
  • Matrix Metalloproteinases / metabolism
  • Postthrombotic Syndrome / immunology*
  • Postthrombotic Syndrome / pathology
  • Postthrombotic Syndrome / prevention & control
  • Stem Cells / immunology
  • Thrombosis / complications
  • Thrombosis / immunology*
  • Thrombosis / pathology
  • Thrombosis / therapy
  • Veins / immunology*
  • Veins / pathology
  • Venous Insufficiency / immunology*
  • Venous Insufficiency / pathology
  • Venous Insufficiency / prevention & control

Substances

  • Chemokines
  • Intercellular Signaling Peptides and Proteins
  • Matrix Metalloproteinases