Activity of citrulline malate on acid-base balance and blood ammonia and amino acid levels. Study in the animal and in man

Arzneimittelforschung. 1991 Jun;41(6):660-3.


An experimental evaluation of citrulline malate (Stimol, CAS 54940-97-5), an anti-fatigue compound, was undertaken in man and in the animal in order to study the pharmacological activity of the substance at hepatic and renal level. In man, the protocol involved a double-blind randomized, placebo-controlled cross-over technique. The study in the animal was blind and placebo-controlled with two randomized parallel groups. Results showed that citrulline malate stimulates hepatic ureogenesis and favorizes the renal reabsorption of bicarbonates. These metabolic actions had a protective effect against acidosis and ammonia poisoning and explain the anti-fatigue properties of citrulline malate in man.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Acid-Base Equilibrium / drug effects*
  • Adult
  • Amino Acids / blood*
  • Ammonia / blood*
  • Animals
  • Citrulline / analogs & derivatives*
  • Citrulline / pharmacology*
  • Double-Blind Method
  • Female
  • Humans
  • Kidney / drug effects
  • Kidney / metabolism
  • Liver / drug effects
  • Liver / metabolism
  • Malates / pharmacology*
  • Male
  • Rats
  • Rats, Inbred Strains


  • Amino Acids
  • Malates
  • Citrulline
  • Ammonia
  • citrulline malate