Transformation of odor representations in target areas of the olfactory bulb

Nat Neurosci. 2009 Apr;12(4):474-82. doi: 10.1038/nn.2288. Epub 2009 Mar 22.

Abstract

The brain generates coherent perceptions of objects from elementary sensory inputs. To examine how higher-order representations of smells arise from the activation of discrete combinations of glomeruli, we analyzed transformations of activity patterns between the zebrafish olfactory bulb and two of its telencephalic targets, Vv and Dp. Vv is subpallial whereas Dp is the homolog of olfactory cortex. Both areas lack an obvious topographic organization but perform complementary computations. Responses to different odors and their mixtures indicate that Vv neurons pool convergent inputs, resulting in broadened tuning curves and overlapping odor representations. Neuronal circuits in Dp, in contrast, produce a mixture of excitatory and inhibitory synaptic inputs to each neuron that controls action potential firing in an odor-dependent manner. This mechanism can extract information about combinations of molecular features from ensembles of active and inactive mitral cells, suggesting that pattern processing in Dp establishes representations of odor objects.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Action Potentials / physiology
  • Animals
  • Brain Mapping
  • Calcium Signaling / drug effects
  • Calcium Signaling / physiology
  • GABA Antagonists / pharmacology
  • Imaging, Three-Dimensional / methods
  • Microscopy, Confocal / methods
  • Nerve Net / cytology
  • Nerve Net / drug effects
  • Nerve Net / physiology
  • Neurons / classification
  • Neurons / physiology*
  • Odorants*
  • Olfactory Bulb / cytology
  • Olfactory Bulb / physiology*
  • Olfactory Pathways / cytology
  • Olfactory Pathways / physiology*
  • Patch-Clamp Techniques
  • Pyridazines / pharmacology
  • Smell / physiology*
  • Stimulation, Chemical
  • Telencephalon / physiology
  • Zebrafish

Substances

  • GABA Antagonists
  • Pyridazines
  • gabazine