Antibody response to pneumococcal vaccination in the elderly

Zentralbl Bakteriol. 1991 Apr;275(1):94-9. doi: 10.1016/s0934-8840(11)80772-3.


In order to evaluate the antibody response to primary pneumococcal vaccination in the elderly, 20 healthy persons aged 60 years or older, (mean age 62.8) were vaccinated with a 23-valent pneumococcal polysaccharide vaccine (Pneumovax 23). Blood samples were taken before and 4 weeks after vaccination and pneumococcal antibody concentrations were measured by ELISA and compared with those obtained after vaccination of younger persons (mean age 39 years). Significantly lower anti-type 2 antibody concentrations were found in the elderly after vaccination. Apart from this, no other significant differences were found neither in pre- and post-vaccination antibody concentrations nor in antibody fold increases between the two groups.

MeSH terms

  • Adult
  • Age Factors
  • Aged
  • Antibodies, Bacterial / biosynthesis*
  • Bacterial Vaccines / immunology*
  • Humans
  • Middle Aged
  • Pneumococcal Infections / immunology*
  • Pneumococcal Vaccines
  • Streptococcus pneumoniae / immunology*


  • Antibodies, Bacterial
  • Bacterial Vaccines
  • Pneumococcal Vaccines