Two cases of hemichorea-hemiballism with nonketotic hyperglycemia: a new point of view

Neurol Sci. 2009 Jun;30(3):179-83. doi: 10.1007/s10072-009-0039-5. Epub 2009 Mar 21.


Hemichorea-hemiballism (HCHB) is an usually continuous, nonpatterned, involuntary movement disorder caused by basal ganglia dysfunction, commonly due to a vascular lesion, described in nonketotic hyperglycemic patients. Particular computed tomography and magnetic resonance imaging findings have been described. The pathogenic mechanism of chorea arising during hyperglycemia and the nature of neuroimaging findings are unclear. In this paper we describe two elderly women with onset of HCHB during a hyperglycemic episode. The symptoms persisted in one of them after recovery of normal glycemia. The pathophysiological mechanism of the disease is discussed in the light of clinical and neuroradiological follow-up.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Aged, 80 and over
  • Basal Ganglia Diseases / complications*
  • Basal Ganglia Diseases / diagnostic imaging
  • Basal Ganglia Diseases / pathology
  • Chorea / complications*
  • Chorea / diagnostic imaging
  • Chorea / pathology
  • Dyskinesias / complications*
  • Dyskinesias / diagnostic imaging
  • Dyskinesias / pathology
  • Female
  • Follow-Up Studies
  • Functional Laterality
  • Humans
  • Hyperglycinemia, Nonketotic / complications*
  • Magnetic Resonance Imaging
  • Tomography, X-Ray Computed