Syk and pTyr'd: Signaling through the B cell antigen receptor

Biochim Biophys Acta. 2009 Jul;1793(7):1115-27. doi: 10.1016/j.bbamcr.2009.03.004. Epub 2009 Mar 21.


The B cell receptor (BCR) transduces antigen binding into alterations in the activity of intracellular signaling pathways through its ability to recruit and activate the cytoplasmic protein-tyrosine kinase Syk. The recruitment of Syk to the receptor, its activation and its subsequent interactions with downstream effectors are all regulated by its phosphorylation on tyrosine. This review discusses our current understanding of how this phosphorylation regulates the activity of Syk and its participation in signaling through the BCR.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Humans
  • Intracellular Signaling Peptides and Proteins / metabolism*
  • Phosphorylation
  • Protein-Tyrosine Kinases / metabolism*
  • Receptors, Antigen, B-Cell / metabolism*
  • Signal Transduction*
  • Syk Kinase
  • Tyrosine / metabolism*


  • Intracellular Signaling Peptides and Proteins
  • Receptors, Antigen, B-Cell
  • Tyrosine
  • Protein-Tyrosine Kinases
  • SYK protein, human
  • Syk Kinase