Decrypting the genome's alternative messages

Curr Opin Cell Biol. 2009 Jun;21(3):377-86. doi: 10.1016/j.ceb.2009.02.006. Epub 2009 Mar 21.

Abstract

Alternative splicing of messenger RNA (mRNA) precursors affects the majority of human genes, has a considerable impact on eukaryotic gene function and offers distinct opportunities for regulation. Alterations in alternative splicing can cause or modify the progression of a significant number of pathologies. Recent high-throughput technologies have uncovered a wealth of transcript diversity generated by alternative splicing, as well as examples for how this diversity can be established and become misregulated. A variety of mechanisms modulate splice site choice coordinately with other cellular processes, from transcription and mRNA editing or decay to miRNA-based regulation and telomerase function. Alternative splicing studies can contribute to our understanding of multiple biological processes, including genetic diversity, speciation, cell/stem cell differentiation, nervous system function, neuromuscular disorders and tumour progression.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Alternative Splicing*
  • Animals
  • Genome*
  • Genome, Human*
  • Humans
  • RNA Precursors / genetics
  • RNA, Messenger / genetics

Substances

  • RNA Precursors
  • RNA, Messenger