Fertility intentions of HIV-1 infected and uninfected women in Malawi: a longitudinal study

AIDS Behav. 2009 Jun;13 Suppl 1:20-7. doi: 10.1007/s10461-009-9547-9. Epub 2009 Mar 24.


This study aimed to determine changes in fertility intentions of HIV-1 infected and uninfected reproductive age women in Blantyre, Malawi. Participants were asked about their fertility intentions at baseline and at 3-month visits for 1 year. Time-to-event statistical models were used to determine factors associated with changes in fertility intentions. Overall, 842 HIV uninfected and 844 HIV infected women were enrolled. The hazard of changing from wanting no more children at baseline to wanting more children at follow-up was 61% lower among HIV infected women compared to HIV uninfected women (P < 0.01) after adjusting for other factors, while HIV infected women were approximately 3 times more likely to change to wanting no more children. The overall pregnancy rate after 12 months was 14.9 per 100 person-years and did not differ among 102 HIV uninfected and 100 infected women who became pregnant. HIV infection is a significant predictor of fertility intentions over time.

Publication types

  • Clinical Trial, Phase III
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Anti-Bacterial Agents / administration & dosage
  • Anti-Bacterial Agents / therapeutic use
  • Family Planning Services*
  • Female
  • Fertility*
  • HIV Infections / psychology*
  • HIV-1
  • Humans
  • Intention*
  • Longitudinal Studies
  • Malawi
  • Metronidazole / administration & dosage
  • Metronidazole / therapeutic use
  • Pregnancy
  • Pregnancy Rate
  • Treatment Outcome
  • Vaginal Creams, Foams, and Jellies / administration & dosage
  • Vaginal Creams, Foams, and Jellies / therapeutic use
  • Vaginosis, Bacterial / drug therapy
  • Women's Health*
  • Young Adult


  • Anti-Bacterial Agents
  • Vaginal Creams, Foams, and Jellies
  • Metronidazole