Solution structure of a locked nucleic acid modified quadruplex: introducing the V4 folding topology

Angew Chem Int Ed Engl. 2009;48(17):3099-103. doi: 10.1002/anie.200806244.


Sharp curves: The structure of a locked nucleic acid modified telomeric sequence from Oxytricha nova displays a remarkable folding topology, distinct from the native O. nova quadruplex. Each guanine stretch folds back in a V-shaped turn that puts the first and fourth guanines in the same tetrad, looping over a tetrad with a sharp turn in the DNA backbone, showing how subtle interplay between sequence and conformation defines the folding topology.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Pairing
  • G-Quadruplexes*
  • Nucleic Acid Conformation*
  • Oligonucleotides / chemistry*


  • Oligonucleotides
  • locked nucleic acid