[Central and peripheral monitoring of the cellular redox state after reduced glutathione administration in the rat]

Boll Soc Ital Biol Sper. 1991 Mar;67(3):267-72.
[Article in Italian]


In this study we measured reduced glutathione as DTNB reactive material in different brain areas as well as in liver and kidney of rat, before and after exogenous administration of GSH. Treatment with GSH produced an increase in DTNB positive material as well as a decrease of lipoperoxidation, in central and peripheral organs of rat, suggesting the possibility of an exogenous modulation of redox balance in mammalian cells.

Publication types

  • Comparative Study
  • English Abstract

MeSH terms

  • Animals
  • Brain Chemistry / drug effects
  • Glutathione / analysis*
  • Glutathione / pharmacokinetics
  • Glutathione / pharmacology
  • Kidney / chemistry
  • Kidney / drug effects
  • Lipid Peroxidation / drug effects
  • Liver / chemistry
  • Liver / drug effects
  • Male
  • Malondialdehyde / analysis
  • Oxidation-Reduction
  • Oxygen / metabolism*
  • Rats
  • Rats, Inbred Strains


  • Malondialdehyde
  • Glutathione
  • Oxygen