[Nasal provocation test with histamine: rhinomanometry study of normal subjects]

Boll Soc Ital Biol Sper. 1991 Mar;67(3):319-26.
[Article in Italian]


Nasal reactivity to histamine was evaluated in 40 normal subjects. The application of a chloride histamine solution (1 mg) registered in 90% of the subjects the appearance of sneezing with the number of sneezes ranging between one and fourteen (5.7 +/- 3.76) and an average increase in the total resistence in the inspiration phase of 93.1% (+/- 63.2) and in the expiration phase of 98.1% (+/- 60.5) with a range between 37.7% and 24.1%. The authors conclude that sneezing and above all nasal congestion evaluated rhinomanometrically represent two important parameters in the evaluation of nasal reaction; an increase greater than or equal to 200% of the total nasal resistance can surely be considered an index of nasal hyperreactivity.

Publication types

  • English Abstract

MeSH terms

  • Adolescent
  • Adult
  • Airway Resistance
  • Female
  • Histamine* / pharmacology
  • Humans
  • Male
  • Manometry
  • Middle Aged
  • Nasal Provocation Tests*
  • Reference Values
  • Sneezing / drug effects


  • Histamine