Abstract
A cobalt-catalyzed cross-coupling of aryl halides with 2-chloropyrimidines or 2-chloropyrazines is reported in satisfactory to high yields. The key step of this procedure is the formation of aromatic organozinc reagents and their coupling with 2-chlorodiazines using the same cobalt halide as catalyst and Zn dust under mild reaction conditions. This new cobalt-catalyzed coupling reaction represents a practical and interesting alternative to previously known methods for the synthesis of 2-aryldiazines.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Catalysis
-
Cobalt / chemistry*
-
Cross-Linking Reagents
-
Hydrocarbons, Chlorinated / chemistry*
-
Indicators and Reagents / chemistry
-
Magnetic Resonance Spectroscopy
-
Molecular Structure
-
Pyrazines / chemical synthesis*
-
Pyrazines / chemistry*
-
Pyrimidines / chemical synthesis*
-
Pyrimidines / chemistry*
-
Structure-Activity Relationship
-
Zinc Compounds / chemical synthesis*
-
Zinc Compounds / chemistry*
Substances
-
2-chloropyrazine
-
2-chloropyrimidine
-
Cross-Linking Reagents
-
Hydrocarbons, Chlorinated
-
Indicators and Reagents
-
Pyrazines
-
Pyrimidines
-
Zinc Compounds
-
Cobalt