Treatment of inflammatory facial acne with 1,450-nm diode laser in type IV to V Asian skin using an optimal combination of laser parameters

Dermatol Surg. 2009 Apr;35(4):593-600. doi: 10.1111/j.1524-4725.2009.01097.x. Epub 2009 Mar 20.


Background: The 1,450-nm diode laser is effective for the treatment of inflammatory acne, but there is a significant risk of postinflammatory hyperpigmentation (PIH) in Asian skin.

Objective: To determine whether lower fluence and shorter cooling duration of the 1,450-nm diode laser improve acne effectively with minimal PIH in darker skin.

Materials and methods: Twenty-six subjects (skin phototypes IV-V) with inflammatory facial acne received four treatments using the 1,450-nm diode laser with 6-mm spot size 3 to 4 weeks apart. We used three passes with a fluence of 8 J/cm(2) with dynamic cooling of 25 ms to minimize PIH. Serial blinded assessment of acne lesion counts and sebum measurement were evaluated before and up to 6 months after treatment.

Results: Four weeks and 6 months after the last treatment, reduction of mean acne lesions was 29% (p<.01) and 40% (p<.03), respectively, from baseline in the group with moderate acne. Significant improvements of sebum production were noted. Four episodes of temporary PIH (3.8%) were observed out of all treatment sessions.

Conclusion: Use of multiple passes of a 1,450-nm diode laser with lower fluence and shorter dynamic cooling device retains its therapeutic efficacy with substantial reduction of PIH for moderate acne.

MeSH terms

  • Acne Vulgaris / complications
  • Acne Vulgaris / radiotherapy*
  • Adolescent
  • Adult
  • Asian Continental Ancestry Group
  • Face
  • Female
  • Humans
  • Hyperpigmentation / etiology
  • Hyperpigmentation / prevention & control
  • Laser Therapy* / adverse effects
  • Male
  • Young Adult