Transmembrane molecular assemblies regulated by the greater cadherin family

Curr Opin Cell Biol. 1991 Oct;3(5):854-61. doi: 10.1016/0955-0674(91)90060-c.


The cadherin family of cell-cell adhesion molecules is turning out to be much more diverse than previously thought, with members involved in several kinds of intercellular junctions. The adhesive specificity and cytoskeletal interaction of these members varies. Their cytoplasmic terminals are specialized for binding several families of 'mediator' proteins which interconnect to the actin or intermediate filament systems. These multi-molecular complexes have roles not only in cell-cell adhesion, but also in intracellular signalling of developmental information.

Publication types

  • Review

MeSH terms

  • Animals
  • Cadherins / physiology*
  • Cell Communication
  • Cell Membrane / physiology*
  • Humans
  • Membrane Proteins / physiology*
  • Signal Transduction*


  • Cadherins
  • Membrane Proteins