Coordinate interactions of protein tyrosine kinases and protein tyrosine phosphatases in T-cell receptor-mediated signalling

Curr Opin Cell Biol. 1991 Oct;3(5):862-8. doi: 10.1016/0955-0674(91)90061-3.

Abstract

T-cell receptor stimulation leads to a rapid increase in tyrosine phosphorylation which is regulated by both the CD45 transmembrane protein tyrosine phosphatase and by intracellular protein tyrosine kinases. The Src-family members, Fyn and Lck, have been implicated in T-cell receptor signalling and may be regulated by CD45.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Humans
  • Protein Tyrosine Phosphatases / metabolism*
  • Protein-Tyrosine Kinases / metabolism*
  • Receptors, Antigen, T-Cell / metabolism*
  • Signal Transduction*

Substances

  • Receptors, Antigen, T-Cell
  • Protein-Tyrosine Kinases
  • Protein Tyrosine Phosphatases