The early IL-6 and IL-10 response in trauma is correlated with injury severity and mortality

Acta Anaesthesiol Scand. 2009 Apr;53(4):515-21. doi: 10.1111/j.1399-6576.2008.01801.x.


Background: Trauma has previously been shown to influence interleukin (IL)-6 and IL-10 levels, but the association of injury severity and mortality with IL-6 and IL-10 responses in the early phase of accidental trauma remains to be investigated. We wished to describe serum levels of IL-6 and IL-10 in the first 24 h after trauma and to assess the relationship with severity of injury and mortality.

Methods: Prospective, descriptive cohort study in a Level 1 trauma centre, Copenhagen, Denmark. We included 265 consecutive adult trauma patients admitted directly from the accident scene during an 18-month period. Serum levels of IL-6 and IL-10 were measured upon arrival and at 6, 12, and 24 h after admittance using an enzyme-linked immunosorbent assay. Correlation analysis was used to assess the relationship between Injury Severity Score (ISS) and levels of IL-6 and IL-10. Analysis of variance was used to describe the IL-6 and IL-10 concentrations in relation to 30-day mortality in a mixed-effect model repeated measures analysis.

Results: Mortality was 10.9% (29/265) at 30 days. A significant increase of both IL-6 and IL-10 concentrations was found over time, and a significant correlation was found between ISS and the levels of both IL-6 and IL-10 at all sampling points. Serum concentrations of IL-6 and IL-10 were significantly higher in patients not surviving 30 days (P<0.0001).

Conclusion: The early systemic inflammatory response measured as IL-6 and IL-10 in serum is correlated with injury severity and 30-day mortality following trauma.

MeSH terms

  • Adult
  • Aged
  • Female
  • Humans
  • Injury Severity Score*
  • Interleukin-10 / blood*
  • Interleukin-6 / blood*
  • Logistic Models
  • Male
  • Middle Aged
  • Wounds and Injuries / immunology*
  • Wounds and Injuries / mortality*


  • Interleukin-6
  • Interleukin-10