B cells in HIV infection and disease

Nat Rev Immunol. 2009 Apr;9(4):235-45. doi: 10.1038/nri2524.


In recent years, intense research efforts have been dedicated to elucidating the pathogenic mechanisms of HIV-associated disease progression. In addition to the progressive depletion and dysfunction of CD4(+) T cells, HIV infection also leads to extensive defects in the humoral arm of the immune system. The lack of immune control of the virus in almost all infected individuals is a great impediment to the treatment of HIV-associated disease and to the development of a successful HIV vaccine. This Review focuses on advances in our understanding of the mechanisms of B-cell dysfunction in HIV-associated disease and discusses similarities with other diseases that are associated with B-cell dysfunction.

Publication types

  • Research Support, N.I.H., Intramural
  • Review

MeSH terms

  • Anti-Retroviral Agents / pharmacology
  • Anti-Retroviral Agents / therapeutic use
  • Antibody Formation / immunology
  • B-Lymphocyte Subsets / immunology
  • B-Lymphocyte Subsets / virology
  • B-Lymphocytes / immunology*
  • B-Lymphocytes / virology
  • Disease*
  • HIV Infections / etiology
  • HIV Infections / immunology*
  • HIV Infections / physiopathology
  • Humans
  • Immune System / drug effects
  • Immune System / immunology
  • Immune System / physiopathology
  • Models, Immunological
  • Viremia / drug therapy
  • Viremia / immunology
  • Viremia / physiopathology


  • Anti-Retroviral Agents