The alcohol flushing response: an unrecognized risk factor for esophageal cancer from alcohol consumption

PLoS Med. 2009 Mar 24;6(3):e50. doi: 10.1371/journal.pmed.1000050.

Abstract

Philip Brooks and colleagues discuss evidence linking the alcohol flushing response (predominantly due to ALDH2 deficiency) with a much higher risk of esophageal cancer from alcohol consumption.

Publication types

  • Review

MeSH terms

  • Acetaldehyde / metabolism
  • Adult
  • Alcohol Drinking / adverse effects*
  • Alcohol Drinking / psychology
  • Alcoholism / epidemiology
  • Aldehyde Dehydrogenase / deficiency
  • Aldehyde Dehydrogenase / genetics*
  • Aldehyde Dehydrogenase / physiology
  • Aldehyde Dehydrogenase, Mitochondrial
  • Asian Continental Ancestry Group / genetics
  • Carcinoma, Squamous Cell / chemically induced*
  • Carcinoma, Squamous Cell / epidemiology
  • Carcinoma, Squamous Cell / ethnology
  • Carcinoma, Squamous Cell / genetics
  • Carcinoma, Squamous Cell / prevention & control
  • DNA Damage
  • Early Diagnosis
  • Esophageal Neoplasms / chemically induced*
  • Esophageal Neoplasms / epidemiology
  • Esophageal Neoplasms / ethnology
  • Esophageal Neoplasms / genetics
  • Esophageal Neoplasms / prevention & control
  • Ethanol / adverse effects*
  • Ethanol / pharmacokinetics
  • Far East / epidemiology
  • Flushing / chemically induced*
  • Flushing / ethnology
  • Flushing / genetics
  • Genetic Predisposition to Disease
  • Humans
  • Middle Aged
  • Patient Education as Topic
  • Risk Factors
  • Social Behavior
  • Surveys and Questionnaires

Substances

  • Ethanol
  • ALDH2 protein, human
  • Aldehyde Dehydrogenase
  • Aldehyde Dehydrogenase, Mitochondrial
  • Acetaldehyde