Abstract
Philip Brooks and colleagues discuss evidence linking the alcohol flushing response (predominantly due to ALDH2 deficiency) with a much higher risk of esophageal cancer from alcohol consumption.
MeSH terms
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Acetaldehyde / metabolism
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Adult
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Alcohol Drinking / adverse effects*
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Alcohol Drinking / psychology
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Alcoholism / epidemiology
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Aldehyde Dehydrogenase / deficiency
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Aldehyde Dehydrogenase / genetics*
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Aldehyde Dehydrogenase / physiology
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Aldehyde Dehydrogenase, Mitochondrial
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Asia, Eastern / epidemiology
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Asian People / genetics
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Carcinoma, Squamous Cell / chemically induced*
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Carcinoma, Squamous Cell / epidemiology
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Carcinoma, Squamous Cell / ethnology
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Carcinoma, Squamous Cell / genetics
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Carcinoma, Squamous Cell / prevention & control
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DNA Damage
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Early Diagnosis
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Esophageal Neoplasms / chemically induced*
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Esophageal Neoplasms / epidemiology
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Esophageal Neoplasms / ethnology
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Esophageal Neoplasms / genetics
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Esophageal Neoplasms / prevention & control
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Ethanol / adverse effects*
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Ethanol / pharmacokinetics
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Flushing / chemically induced*
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Flushing / ethnology
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Flushing / genetics
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Genetic Predisposition to Disease
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Humans
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Middle Aged
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Patient Education as Topic
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Risk Factors
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Social Behavior
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Surveys and Questionnaires
Substances
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Ethanol
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ALDH2 protein, human
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Aldehyde Dehydrogenase
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Aldehyde Dehydrogenase, Mitochondrial
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Acetaldehyde