Isolation of 2-pyridone alkaloids from a New Zealand marine-derived penicillium species

J Nat Prod. 2009 Mar 27;72(3):477-9. doi: 10.1021/np800627f.

Abstract

Fermentation of a Penicillium sp. isolated from a surface-sterilized thallus segment of the brown alga Xiphophora gladiata, collected from Macrocarpa Point, Otago, New Zealand, in half-strength potato dextrose broth led to the isolation and characterization of three alkaloids: the known N-hydroxy-2-pyridone, PF1140 (1), and two new 2-pyridones, 2 and 3.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkaloids / chemistry
  • Alkaloids / isolation & purification*
  • Animals
  • Benzopyrans / chemistry
  • Benzopyrans / isolation & purification
  • Leukemia P388
  • Marine Biology
  • Mice
  • Molecular Structure
  • New Zealand
  • Penicillium / chemistry*
  • Phaeophyta / microbiology
  • Pyridones / chemistry
  • Pyridones / isolation & purification*
  • Structure-Activity Relationship

Substances

  • Alkaloids
  • Benzopyrans
  • PF 1140
  • Pyridones
  • 2-hydroxypyridine