Glutamate receptor gene (GRIN2B) associated with reduced anterior cingulate glutamatergic concentration in pediatric obsessive-compulsive disorder

Psychiatry Res. 2009 May 15;172(2):136-9. doi: 10.1016/j.pscychresns.2009.02.005. Epub 2009 Mar 25.


In this preliminary study, 16 psychotropic-naïve pediatric patients with obsessive-compulsive disorder (OCD) were studied using magnetic resonance spectroscopy (MRS) and genotyped for six candidate polymorphisms in two glutamate system genes. A significant association was identified between the rs1019385 polymorphism of the glutamate receptor, ionotropic, N-methyl-d-aspartate 2B (GRIN2B) and decreased anterior cingulate cortex (ACC) glutamatergic concentration (Glx) but not with occipital Glx. These results suggest that GRIN2B may be associated with Glx in the ACC, a region consistently implicated in OCD.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Age Factors
  • Brain
  • Child
  • Female
  • Genetic Variation
  • Genotype
  • Glutamic Acid / analysis
  • Glutamic Acid / metabolism*
  • Gyrus Cinguli / metabolism*
  • Humans
  • Magnetic Resonance Spectroscopy
  • Male
  • Obsessive-Compulsive Disorder / genetics*
  • Obsessive-Compulsive Disorder / metabolism
  • Occipital Lobe / metabolism
  • Polymorphism, Genetic
  • Receptors, N-Methyl-D-Aspartate / genetics*
  • Receptors, N-Methyl-D-Aspartate / metabolism


  • NR2B NMDA receptor
  • Receptors, N-Methyl-D-Aspartate
  • Glutamic Acid