Thermus thermophilus strains active in purine nucleoside synthesis

Molecules. 2009 Mar 24;14(3):1279-87. doi: 10.3390/molecules14031279.


Several strains of Thermus thermophilus were tested in order to detect purine nucleoside synthase activity using pyrimidine nucleosides as the sugar-donor and adenine or hypoxanthine as bases. High productivity values (t =1 hr) were obtained while completely avoiding adenosine-deaminase degradation of the products. N-2-deoxy-ribosyltransferase activity is described for the first time in hyperthermophilic bacteria.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenine / metabolism
  • Hypoxanthine / metabolism
  • Kinetics
  • Pentosyltransferases
  • Purine Nucleosides / biosynthesis*
  • Pyrimidine Nucleosides / metabolism
  • Thermus thermophilus / enzymology
  • Thermus thermophilus / metabolism*


  • Purine Nucleosides
  • Pyrimidine Nucleosides
  • Hypoxanthine
  • Pentosyltransferases
  • nucleoside deoxyribosyltransferase II
  • Adenine