Effects of naringin on the proliferation and osteogenic differentiation of human bone mesenchymal stem cell

Eur J Pharmacol. 2009 Apr 1;607(1-3):1-5. doi: 10.1016/j.ejphar.2009.01.035.


Rhizoma drynariae is used commonly in the treatment of osteoporosis and bone nonunion in traditional Chinese medicine. Modern pharmacological research indicates that naringin is the main effective component of rhizoma drynariae, which can induce the expression of the osteogenic marker in the osteoblast cell line. However, no former study has described its effect on bone mesenchymal stem cells (BMSCs). In our experiment, we co-cultured human BMSCs with different concentrations of naringin solution, then the osteogenic differentiation markers and proliferation ability were analyzed. The results indicated that a certain concentration (1-100 microg/ml) of the naringin solution may enhance the proliferation and osteogenic differentiation of human BMSCs. Also, our research explains excellently the anti-osteoporotic and bone nonunion treatment mechanism of rhizoma drynariae, thus contributing to the exploration of osteogenic differentiation agents from Chinese herbs.

MeSH terms

  • Biomarkers / metabolism
  • Cell Differentiation / drug effects*
  • Cell Proliferation / drug effects*
  • Cells, Cultured
  • Dose-Response Relationship, Drug
  • Flavanones / administration & dosage
  • Flavanones / isolation & purification
  • Flavanones / pharmacology*
  • Humans
  • Medicine, Chinese Traditional
  • Mesenchymal Stem Cells / drug effects*
  • Mesenchymal Stem Cells / metabolism
  • Osteogenesis / drug effects
  • Polypodiaceae / chemistry


  • Biomarkers
  • Flavanones
  • naringin