Surgical sutures capable of drug loading and sustained release are important in wound healing applications. In this work, a facile way to incorporate anti-inflammatory drug of ibuprofen in surgical sutures has been established. First, surgical sutures were deposited with multilayer films containing microgels of chemically cross-linked poly(allylamine hydrochloride) (PAH) and dextran (named PAH-D) by layer-by-layer deposition of PAH-D and hyaloplasm acid (HA). Ibuprofen was then incorporated in the PAH-D/HA films to obtain ibuprofen-loaded sutures. Ibuprofen incorporated in the surgical sutures can be released in 0.9% normal saline in a sustainable way. The successful incorporation of ibuprofen in surgical sutures depends largely on PAH-D microgels, which can deposit directly on the hydrophobic surgical sutures without any surface modification and load ibuprofen based on electrostatic interaction between them. The present study provides a facile and generally applicable way to incorporate drugs in surgical sutures that is highly useful to accelerate the healing of cuts and wounds.