A novel mutation in LAMIN A/C is associated with isolated early-onset atrial fibrillation and progressive atrioventricular block followed by cardiomyopathy and sudden cardiac death

Heart Rhythm. 2009 May;6(5):707-10. doi: 10.1016/j.hrthm.2009.01.037. Epub 2009 Feb 4.
No abstract available

Publication types

  • Case Reports
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Atrial Fibrillation / etiology
  • Atrial Fibrillation / genetics*
  • Atrial Fibrillation / metabolism
  • Atrioventricular Block / etiology
  • Atrioventricular Block / genetics*
  • Atrioventricular Block / metabolism
  • Cardiomyopathy, Dilated / complications*
  • Cardiomyopathy, Dilated / genetics
  • Cardiomyopathy, Dilated / metabolism
  • DNA / genetics*
  • Death, Sudden, Cardiac*
  • Fatal Outcome
  • Female
  • Genetic Predisposition to Disease
  • Humans
  • Lamin Type A / genetics*
  • Lamin Type A / metabolism
  • Lipodystrophy
  • Male
  • Middle Aged
  • Mutation*

Substances

  • LMNA protein, human
  • Lamin Type A
  • DNA