Intricate links between ER stress and apoptosis

Mol Cell. 2009 Mar 27;33(6):669-70. doi: 10.1016/j.molcel.2009.03.002.

Abstract

Bax inhibitor-1 (BI-1) interacts with Bax, neutralizing its proapoptotic activity. In this issue of Molecular Cell, Lisbona et al. (2009) show that BI-1 directly inhibits IRE1alpha, an essential mediator of the UPR, thereby facilitating crosstalk between apoptosis and ER stress pathways.

Publication types

  • Comment

MeSH terms

  • Apoptosis / physiology*
  • Apoptosis Regulatory Proteins / genetics
  • Apoptosis Regulatory Proteins / metabolism*
  • Endoplasmic Reticulum / physiology*
  • Endoribonucleases / genetics
  • Endoribonucleases / metabolism*
  • Humans
  • Membrane Proteins / genetics
  • Membrane Proteins / metabolism*
  • Protein-Serine-Threonine Kinases / genetics
  • Protein-Serine-Threonine Kinases / metabolism*

Substances

  • Apoptosis Regulatory Proteins
  • Membrane Proteins
  • TMBIM6 protein, human
  • ERN1 protein, human
  • Protein-Serine-Threonine Kinases
  • Endoribonucleases