Numerous manufacturers are marketing topical creams, claiming that they improve or eliminate unwanted fat or cellulite in a short period of time. The active ingredient in most of these creams is theophylline, and claims have been made that it initiates lipolysis by binding to adipocyte beta-adrenergic receptors. The creams are applied with vigorous massage to facilitate absorption and apply mechanical stress to the fat cells. The efficacy of these creams is largely untested. This prospective randomized study was conducted to determine whether there is scientific evidence that application of these creams alone can eliminate unwanted fat or cellulite. Eleven women with normal body weight as defined by insurance tables applied either Skinny Dip(TM) or a placebo to one thigh and one half of the abdomen for 8 weeks. Each subject was examined, photographed, weighed, and measured by a study monitor on a weekly basis. There were no statistically significant differences in appearance, abdominal circumference, thigh circumference, or skin fold measurements among subjects using the active agent (Skinny Dip(TM)) or the placebo. This study failed to support the efficacy of topically applied lipolytic creams in eliminating unwanted fat manifesting as a localized bulge or cellulite presenting as a dimpling of the skin.