Noradrenergic denervation facilitates the release of acetylcholine and serotonin in the hippocampus: towards a mechanism underlying upregulations described in MCI patients

Exp Neurol. 2009 Jun;217(2):237-9. doi: 10.1016/j.expneurol.2009.03.013. Epub 2009 Mar 25.

Author

Michael T Heneka¹

Affiliation

¹ Department of Neurology, University of Bonn, Sigmund-Freud-Strasse 25, 53105 Bonn, Germany. michael.heneka@ukb.uni-bonn.de

PMID: 19328200
DOI: 10.1016/j.expneurol.2009.03.013

No abstract available

Publication types

Editorial
Comment

MeSH terms

Acetylcholine / metabolism*
Afferent Pathways / metabolism
Afferent Pathways / physiopathology
Animals
Arousal / physiology
Axons / metabolism
Cognition Disorders / drug therapy
Cognition Disorders / metabolism*
Cognition Disorders / physiopathology
Denervation
Hippocampus / drug effects
Hippocampus / metabolism*
Hippocampus / physiopathology
Humans
Locus Coeruleus / metabolism*
Locus Coeruleus / pathology
Locus Coeruleus / physiopathology
Mice
Nerve Degeneration / metabolism
Nerve Degeneration / pathology
Nerve Degeneration / physiopathology
Norepinephrine / deficiency*
Presynaptic Terminals / metabolism
Serotonin / metabolism*
Synaptic Transmission / physiology
Up-Regulation / physiology

Substances

Serotonin
Acetylcholine
Norepinephrine