Functional and anatomic results of amnion vaginoplasty in young women with Mayer-Rokitansky-Küster-Hauser syndrome

Fertil Steril. 2010 Jun;94(1):317-23. doi: 10.1016/j.fertnstert.2009.01.154. Epub 2009 Mar 27.


Objective: To evaluate the surgical outcome and the long-term anatomic and functional results in young women with Mayer-Rokitansky-Küster-Hauser Syndrome (MRKH) undergoing neovaginal creation with amniotic membranes.

Design: Evaluation of surgical and functional outcome according to clinical records and validated questionnaires about sexuality (Female Sexual Function Index [FSFI]) over a 1.5-year follow-up period.

Setting: University hospital and referral center for pediatric and adolescent gynecology.

Patient(s): Seven patients with congenital vaginal aplasia with a mean age of 20.86 +/- 3.56 years (range 17-26 years).

Intervention(s): McIndoe procedure modified by the application of human freeze-dried amniotic membranes.

Main outcome measure(s): Anatomic success was defined by a vaginal length >or=8 cm, and a width allowing the easy introduction of two fingers. FSFI scores were applied to define functional results.

Result(s): Mean neovaginal length was 9.3 cm (range 4-12 cm). The mean FSFI score was 30.0 +/- 6.9. Major operative complications occurred in one patient. In six out of seven patients satisfactory anatomic and functional results were achieved.

Conclusion(s): The surgical dissection of the vesicorectal space and the application of human amnion over a vaginal mold to create a neovagina results in satisfying anatomic and functional outcome with low perioperative morbidity in MRKH patients.

Publication types

  • Comparative Study

MeSH terms

  • Adolescent
  • Adult
  • Amnion / transplantation*
  • Female
  • Follow-Up Studies
  • Gynecologic Surgical Procedures / methods
  • Humans
  • Mullerian Ducts / abnormalities
  • Mullerian Ducts / surgery
  • Plastic Surgery Procedures / methods*
  • Syndrome
  • Treatment Outcome
  • Vagina / abnormalities*
  • Vagina / anatomy & histology
  • Vagina / physiology*
  • Vagina / surgery
  • Young Adult