Characteristics of the antibodies of two patients who developed daytime hyperglycemia and morning hypoglycemia because of insulin antibodies

Tsuneo Ishizuka; Susumu Ogawa; Takefumi Mori; Kazuhiro Nako; Takashi Nakamichi; Yoshitomo Oka; Sadayoshi Ito

doi:10.1016/j.diabres.2009.02.007

Characteristics of the antibodies of two patients who developed daytime hyperglycemia and morning hypoglycemia because of insulin antibodies

Diabetes Res Clin Pract. 2009 May;84(2):e21-3. doi: 10.1016/j.diabres.2009.02.007. Epub 2009 Mar 27.

Authors

Tsuneo Ishizuka¹, Susumu Ogawa, Takefumi Mori, Kazuhiro Nako, Takashi Nakamichi, Yoshitomo Oka, Sadayoshi Ito

Affiliation

¹ Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University School of Medicine, 1-1 Seiryo-cho, Aoba-ku, Sendai 980-8574, Japan.

PMID: 19328577
DOI: 10.1016/j.diabres.2009.02.007

Abstract

We encountered two patients who developed daytime hyperglycemia and early morning hypoglycemia because of insulin antibody (IA) that the affinity was extremely lower and the capacity extremely higher than those of IA in the insulin autoimmune syndrome, after their insulin treatment were changed from human insulin to analog insulin.

Publication types

Case Reports

MeSH terms

Aged, 80 and over
Autoantibodies / blood*
Diabetes Mellitus / blood
Diabetes Mellitus / drug therapy*
Diabetes Mellitus / immunology
Glycated Hemoglobin / metabolism
Humans
Hyperglycemia / blood
Hyperglycemia / immunology*
Hypoglycemia / blood
Hypoglycemia / immunology*
Insulin / analogs & derivatives
Insulin / therapeutic use*
Insulin Antibodies / blood*
Insulin Lispro
Male

Substances

Autoantibodies
Glycated Hemoglobin A
Insulin
Insulin Antibodies
Insulin Lispro