Characteristics of the antibodies of two patients who developed daytime hyperglycemia and morning hypoglycemia because of insulin antibodies

Diabetes Res Clin Pract. 2009 May;84(2):e21-3. doi: 10.1016/j.diabres.2009.02.007. Epub 2009 Mar 27.

Abstract

We encountered two patients who developed daytime hyperglycemia and early morning hypoglycemia because of insulin antibody (IA) that the affinity was extremely lower and the capacity extremely higher than those of IA in the insulin autoimmune syndrome, after their insulin treatment were changed from human insulin to analog insulin.

Publication types

  • Case Reports

MeSH terms

  • Aged, 80 and over
  • Autoantibodies / blood*
  • Diabetes Mellitus / blood
  • Diabetes Mellitus / drug therapy*
  • Diabetes Mellitus / immunology
  • Glycated Hemoglobin A / metabolism
  • Humans
  • Hyperglycemia / blood
  • Hyperglycemia / immunology*
  • Hypoglycemia / blood
  • Hypoglycemia / immunology*
  • Insulin / analogs & derivatives
  • Insulin / therapeutic use*
  • Insulin Antibodies / blood*
  • Insulin Lispro
  • Male

Substances

  • Autoantibodies
  • Glycated Hemoglobin A
  • Insulin
  • Insulin Antibodies
  • Insulin Lispro