Plasma membrane tubulin

Biochim Biophys Acta. 2009 Jul;1788(7):1415-33. doi: 10.1016/j.bbamem.2009.03.013. Epub 2009 Mar 26.

Abstract

The association of tubulin with the plasma membrane comprises multiple levels of penetration into the bilayer: from integral membrane protein, to attachment via palmitoylation, to surface binding, and to microtubules attached by linker proteins to proteins in the membrane. Here we discuss the soundness and weaknesses of the chemical and biochemical evidence marshaled to support these associations, as well as the mechanisms by which tubulin or microtubules may regulate functions at the plasma membrane.

Publication types

  • Review

MeSH terms

  • Cell Membrane / chemistry
  • Cell Membrane / metabolism*
  • Humans
  • Hydrophobic and Hydrophilic Interactions
  • Membrane Proteins / chemistry
  • Membrane Proteins / metabolism*
  • Tubulin / chemistry
  • Tubulin / metabolism*

Substances

  • Membrane Proteins
  • Tubulin