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, 19 (9), 2464-7

3-(Arylamino)-3-phenylpropan-2-olamines as a New Series of Dual Norepinephrine and Serotonin Reuptake Inhibitors

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3-(Arylamino)-3-phenylpropan-2-olamines as a New Series of Dual Norepinephrine and Serotonin Reuptake Inhibitors

An T Vu et al. Bioorg Med Chem Lett.

Abstract

A series of 3-(arylamino)-3-phenylpropan-2-olamines was prepared and screened for their ability to inhibit monoamine reuptake. A number of analogues displayed significant dual norepinephrine and serotonin reuptake inhibition. Compounds in this class exhibited minimal affinity for the dopamine transporter.

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