Synthesis, cytotoxic and combined cDDP activity of new stable curcumin derivatives

Bioorg Med Chem. 2009 Apr 15;17(8):3043-52. doi: 10.1016/j.bmc.2009.03.016. Epub 2009 Mar 14.

Abstract

New curcumin derivatives are synthesized in order to improve chemical properties of curcumin. The aromatic ring glycosylation of curcumin provides more water-soluble compounds with a greater kinetic stability which is a fundamental feature for drug bioavailability. The glycosylation reaction is quite simple, low cost, with high yield and minimum waste. NMR data show that the ability of curcumin to coordinate metal ion, in particular Ga(III), is maintained in the synthesized products. Although the binding of glucose to curcumin reduces the cytotoxicity of the derivatives towards cisplatin (cDDP)-sensitive and -resistant human ovarian carcinoma cell lines, the compounds display a good selectivity since they are much less toxic against non-tumourigenic Vero cells. The combination of cDDP with the most active glycosyl-curcuminoid drug against both cDDP-sensitive and -resistant as well as against Vero cell lines is tested. The results show an improvement of cDDP efficacy with higher selectivity towards cancer cells than non-cancer cells. These studies indicate the need for developing new valid components of drug treatment protocols to cDDP-resistant cells as well.

MeSH terms

  • Animals
  • Antineoplastic Combined Chemotherapy Protocols / pharmacology*
  • Cell Line, Tumor
  • Chlorocebus aethiops
  • Cisplatin / administration & dosage
  • Cisplatin / pharmacology*
  • Curcumin / administration & dosage
  • Curcumin / analogs & derivatives*
  • Curcumin / chemistry
  • Curcumin / pharmacology*
  • Cystadenocarcinoma, Serous / drug therapy*
  • Female
  • Humans
  • Magnetic Resonance Spectroscopy
  • Ovarian Neoplasms / drug therapy*
  • Vero Cells

Substances

  • Curcumin
  • Cisplatin