Methamphetamine and Viagra use: relationship to sexual risk behaviors

Arch Sex Behav. 2011 Apr;40(2):273-9. doi: 10.1007/s10508-009-9495-5. Epub 2009 Mar 28.


Recent studies show that Viagra and methamphetamine use are associated with unprotected anal intercourse among men who have sex with men (MSM). In Long Beach, California, we have reported on an association between Viagra use and the use of amphetamines during sex. The current research investigated the use of both Viagra and amphetamine in men in Long Beach, California. Data on 1,839 men recruited into HIV prevention and testing programs were collected using the Risk Behavior Assessment. A generalized logit model was constructed comparing ever having used both amphetamine and Viagra together and separately, as compared to never having used either (referent). Men who used both methamphetamine and Viagra showed a significantly higher prevalence of hepatitis B, syphilis, and HIV compared to those who used only one or neither drug. Of the 1,794 complete cases, 11.1% (199/1794) had used both amphetamine and Viagra. Of 20 potential risk and protective factors for use of amphetamine and Viagra, 12 were significant predictors: ever used gamma-hydroxybutyrate (GHB), ever used cocaine, ever used ecstasy, being infected with HIV, race=White compared to other, ever having hepatitis B, ever using crack, ever given money to have sex, living in a hotel, ever been in drug treatment, and ever using heroin. The protective factor was being heterosexual. Viagra use was associated with insertive, and methamphetamine was associated with receptive, anal intercourse. GHB use appears to play a more important role than previously thought.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Amphetamine-Related Disorders / epidemiology*
  • Amphetamine-Related Disorders / psychology
  • Chi-Square Distribution
  • HIV Infections / epidemiology
  • Hepatitis B / epidemiology
  • Homosexuality, Male / psychology
  • Homosexuality, Male / statistics & numerical data*
  • Humans
  • Interviews as Topic
  • Male
  • Methamphetamine*
  • Middle Aged
  • Phosphodiesterase 5 Inhibitors*
  • Piperazines*
  • Prevalence
  • Purines
  • Risk Factors
  • Risk-Taking*
  • Sexual Behavior / psychology
  • Sexual Behavior / statistics & numerical data*
  • Sexual Partners
  • Sildenafil Citrate
  • Sulfones*
  • Syphilis / epidemiology


  • Phosphodiesterase 5 Inhibitors
  • Piperazines
  • Purines
  • Sulfones
  • Methamphetamine
  • Sildenafil Citrate