Analysis of factors influencing aspiration risk following chemoradiation for oropharyngeal cancer

Br J Radiol. 2009 Aug;82(980):675-80. doi: 10.1259/bjr/72852974. Epub 2009 Mar 30.

Abstract

Our aim was to identify risk factors for aspiration following concurrent chemoradiation for oropharyngeal cancer. 46 patients with locally advanced oropharyngeal carcinoma underwent concurrent chemoradiation at our institution. All patients underwent modified barium swallow to assess dysphagia severity and to determine the need for continued tube feedings after treatment. Dysphagia severity was graded as 1-7. There were 5 Grade 2, 11 Grade 3, 5 Grade 4, 5 Grade 5, 10 Grade 6 and 10 Grade 7 scores. 25 patients (54%) developed aspiration (5 trace, 20 severe). The aspiration rate for T1-T2 and T3-T4 tumours was 31% and 67%, respectively (p = 0.03). There was no statistical difference in the aspiration rate between the base of the tongue and tonsillar carcinoma (p = 0.23). Despite anatomical organ preservation, most patients with locally advanced oropharyngeal carcinoma had moderate to severe dysphagia after chemoradiation. Patients with large tumours had a significant risk of developing aspiration following treatment.

MeSH terms

  • Aged
  • Antimetabolites, Antineoplastic / administration & dosage
  • Antineoplastic Combined Chemotherapy Protocols / adverse effects
  • Barium Sulfate / administration & dosage
  • Cisplatin / administration & dosage
  • Combined Modality Therapy / adverse effects
  • Contrast Media / administration & dosage
  • Deglutition Disorders / diagnosis
  • Deglutition Disorders / etiology*
  • Fluorouracil / administration & dosage
  • Humans
  • Male
  • Middle Aged
  • Oropharyngeal Neoplasms / drug therapy*
  • Oropharyngeal Neoplasms / radiotherapy*
  • Radiation-Sensitizing Agents / administration & dosage
  • Respiratory Aspiration / etiology*
  • Retrospective Studies
  • Risk Factors
  • Texas
  • Tongue Neoplasms / complications
  • Tongue Neoplasms / drug therapy
  • Tongue Neoplasms / radiotherapy
  • Tonsillar Neoplasms / complications
  • Tonsillar Neoplasms / drug therapy
  • Tonsillar Neoplasms / radiotherapy
  • Treatment Outcome

Substances

  • Antimetabolites, Antineoplastic
  • Contrast Media
  • Radiation-Sensitizing Agents
  • Barium Sulfate
  • Cisplatin
  • Fluorouracil