The biosynthetic potential of myxobacteria and their impact in drug discovery

Curr Opin Drug Discov Devel. 2009 Mar;12(2):220-30.

Abstract

Myxobacteria produce an immense variety of natural products with useful biological activities. This review highlights recent advances to evaluate and further explore their biosynthetic potential for drug discovery, with particular focus on polyketide synthase and non-ribosomal peptide synthetase-derived secondary metabolites.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Anti-Infective Agents / metabolism
  • Antineoplastic Agents / metabolism
  • Biological Products / biosynthesis*
  • Biological Products / chemistry
  • Biological Products / genetics
  • Biological Products / pharmacology
  • Drug Discovery*
  • Gene Expression Regulation, Bacterial
  • Gene Regulatory Networks
  • Humans
  • Myxococcales / enzymology*
  • Myxococcales / genetics
  • Peptide Synthases / metabolism
  • Polyketide Synthases / metabolism
  • Structure-Activity Relationship

Substances

  • Anti-Infective Agents
  • Antineoplastic Agents
  • Biological Products
  • Polyketide Synthases
  • Peptide Synthases
  • non-ribosomal peptide synthase